Lead concentrations in the blood are associated with an increased risk of death from coronary heart diseases (CHD). A study of 533 American women, published in BioMed Central's open access journal Environmental Health, has shown that those with blood lead concentrations above 8μg/dL were three times more likely to die of CHD.

Naila Khalil worked with a team of researchers from the University of Pittsburgh and the University of Maryland to study the effects of lead on the mortality of a group of 65-87 year old women who had joined an earlier study between 1986 and 1988. These women have been followed ever since and their causes of death recorded. Khalil said, "Despite population-wide declines in blood lead concentrations during the past 30 years, environmental lead exposure continues to be a public health concern. Lead is a toxic metal, and our results add to the existing evidence of adverse affects of lead on health as seen in an older cohort who experienced greater historic environmental lead exposure".

The average population blood lead concentration in the most recent US National Health and Nutrition Examination Survey (2001-2002) had declined to 1.45μg/dL. The women studied in Dr. Khalil's research, however, were alive while lead was still used in paints, water systems and as a gasoline additive. They had an average blood concentration of 5.3μg/dL, with some women showing levels as high as 21μg/dL. According to Khalil, "Women with a blood lead concentration above 8μg/dL had a 73% increased risk of dying. In particular, blood lead was associated with almost three-fold risk in CHD mortality".

This study shows that environmental toxicants, such as lead, may account for some of the burden of cardiovascular disease, which is the leading cause of mortality worldwide. It kills nearly half a million women in the United States every year, more than the next five causes of death combined and nearly twice as many as all forms of cancer, including breast cancer. The authors conclude, "While the damage may already have been done for some older people, it is important that we recognize the harm that environmental exposure to lead can cause. We must remain vigilant and ensure that lead pollution is minimized for the sake of future generations' health".

Notes:

1. Association of blood lead concentrations with mortality in older women: a prospective cohort study
Naila Khalil, John W Wilson, Evelyn O Talbott, Lisa A Morrow, Marc C Hochberg, Teresa A Hillier, Susan B Muldoon, Steven R Cummings and Jane A Cauley
Environmental Health (in press)
After the embargo, article available at the journal website: ehjournal/
All articles are available free of charge, according to BioMed Central's open access policy.

2. Environmental Health is an Open Access, peer-reviewed, online journal that considers manuscripts on all aspects of environmental and occupational medicine, and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. It is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.

3. BioMed Central (biomedcentral/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

Source:
Graeme Baldwin
BioMed Central