New data presented at the International Liver CongressTM 2010 found a link between chronic hepatitis B virus (HBV) and progression to cancers other than hepatocellular carcinoma.

The study found that a higher risk of Non-Hodgkin Lymphoma (NHL) and Cholangiocarcinoma was associated with HBV infection in the presence of higher levels of viral replication.

The data could indicate a causal effect for HBV infection and if proven to be the case in further trials, the benefits of a vaccine against and treatment of HBV will extend beyond reduction in hepatocellular carcinoma.

Worldwide, more than 350 million people are persistently infected with HBV and chronic HBV causes about 1 million deaths each year.

NHL is any of a large group of cancers of the lymphoid system (white blood cells) that can occur at any age. About 80% of all lymphomas diagnosed are NHL and NHL account for 4% of all cancers in the UK.

Cholangiocarcinoma is a cancer of the bile duct cells with no medical treatment except surgery. It is relatively rare with an annual incidence of 1 case per 100,000 in the Western world, although rates are increasing.

Source:
Isabelle Scali
European Association for the Study of the Liver